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Question |
Lot of anti sickling agents have been mentioned in books besides butyrates .But further information is not available in latest journals or textbooks. Kindly discuss it. 2) We have a case of neonatal thrombocytopenia which mentioning briefly. Mother HIV +VE,totally asymptomatic except moderate splenomegaly. patelet count 72000/mm,delivered be caserean. Baby brought for routine follow up on 2nd week of life. THROMBOCYTE count 52000 . baby called for follow up for every week. count 50000 & 16,000 (sixteen thousand) respectively.Baby totally asympto matic at all visits. PBS SHOWS GIANT PLATELETS BUT COAGULATION PROFILE NORMAL. wHAT SHOULD BE FURTHER plan of action?Will antiplatelet antibodies test necessary? Should we transfuse the baby or give steroids? is mother or baby's bone marrow indicated? (if any further infi reqed please let me know)
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Answer |
Thrombocytopenia is a known problem in HIV infected patients. The causes vary and include antiplatelet antibodies as in ITP, bone marrow suppression due to drugs, opportunistic infections and even by HIV virus itself. In most patients, antiplatelet antibodies would be positive.
Since the baby also has thrombocytopenia, it is most likely a neonatal alloimmune thrombocytopenia. Treatment would be the same as in a seronegative patient.
Read the article on "NEONATAL THROMBOCYTOPENIA - A CHALLENGE" on www.pediatriconcall.com or from the link given below:
http://www.pediatriconcall.com/fordoctor/diseasesandcondition/neonatal_thrombo.asp
Regarding Sickle cell anemia, we will let you know as soon as the article is put online.
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