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| SPECIALIST ANSWERS
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Question |
Is it possible in widal test case That O anti body found negative and H antibody are 360 titre positive.What will be the interpretation of O anti body negative and and H antibody 360 positive report in widal test
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Answer |
An increasing O antibody level signifies acute infection, whilst a raised H antibody level may indicate the serotype of the infecting organism.
Widal's test is of limited use because H and O antibody levels may rise non-specifically due to cross reactions with other enterobacteriacea.
However in studies it has been found that over 6% of patients with bacteriologically proven typhoid fever may have significantly raised H titre and negative O titre. Thus both O and H titre are of importance and Widal test should be interpreted with clinical features.
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