Drug Related (Iatrogenic) Blood Abnormalities & Serum Artefacts
Dr Ira Shah
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Drug Related (Iatrogenic) Blood Abnormalities & Serum Artefacts - Introduction
PATTERN IN SALICYLATES INGESTION
Commonest cause of high uric acid level is salicylates ingestion . Diuretics also raise uric acid levels.

BIOCHEMICAL TEST NORMAL RANGE PATIENT VALUES
LOW NORMAL HIGH
S. URIC ACID 2.1 - 7.4 mg / dl     *


PATTERN FOLLOWING DIURETIC THERAPY
Elevated uric acid and low Na+ and Cl levels are commonly observed.

BIOCHEMICAL TEST NORMAL RANGE PATIENT VALUES
LOW NORMAL HIGH
CALCIUM
A - 8.5 - 10.5 mg / dl
C - 9.5 - 11.0 mg /dl
  *  
PHOSPHORUS
A - 2.5 - 4.5 mg / dl
C - 2.5 - 5.5 mg / dl
  *  
S.URIC ACID 2.1 - 7.4 mg / dl     *
SODIUM
137 - 148mEq / L *    
POTASSIUM
3.5 - 5.6mEq / L   *  
CHLORIDES 99 - 108mEq / L *    
BICARBONATE 23.7 - 31.4mEq / L   *  
  A - Adult. C - Child,      


PATTERN OF HEMOLYSED SERUM
Depending upon degree of hemolysis (in vitro), LDH, HBDH & SGOT will be elevated.

BIOCHEMICAL TEST NORMAL RANGE PATIENT VALUES
LOW NORMAL HIGH
HBDH (UV KINETIC) 90 - 220 IU / L     *
LDH (UV KINETIC) 40 - 110 IU / L     *
SGOT (UV KINETIC) 7 - 24 IU / L     *


PATTERN OF NON - FASTING SAMPLE
High levels of triglycerides, cholesterol, urea & alkaline phosphatase may be observed in non fasting samples.

BIOCHEMICAL TEST NORMAL RANGE PATIENT VALUES
LOW NORMAL HIGH
TRIGLYCERIDES 35 - 165 mg / dl     *
CHOLESTEROL(Enzymatic) 125 - 225 mg / dl   *  
ALK. PHOSPHATASE(KINETIC) A - 15 - 65 IU / L
C - 70 - 150 IU / L
    *
BLOOD UREA(KINETIC) 15 - 45 mg / dl   *  
  A - Adult. C - Child,  


These normal laboratory values may slightly vary from laboratory to laboratory. Please consult your lab for the same.


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