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5TH NATIONAL CONFERENCE OF PEDIATRIC RHEUMATOLOGY, KOLKATA, 29TH & 30TH SEPTEMBER 2007
Arpita Roychowdhri*
Abhijit Tarafdar**
*DM Senior Resident, **Professor & Head
Department of Nephrology, IPGMER, Kolkata
SLE nephritis is being reported even at < 2yrs of age with a poor prognosis. Prevalence of pediatric SLE is 15% and it is more common among Asians, native Americans, blacks and Polynesians. Lupus nephritis is observed in all most all children with SLE. To begin with severe nephritis initially may not be associated any changes in creatinine clearance, proteinuria or abnormal urinary sediment. Renal biopsy is essential in lupus nephritis for prognostication and therapeutic intervention. Outcome is poorest in class IV lupus nephritis and best in children with minimal or controlled systemic disease. Management of pediatric SLE nephritis includes good induction therapy to prevent flare and avoidance of renal damage, improvement of patient’s QOL and psychosocial development. This is achieved with standard immuno suppresives like cyclophosphamide, corticosteriod, azothioprine, hydroxychloroquine, cyclosporine & MMF. Standard protocols for treatment of lupus nephritis are not much different from adult nephritis management. The present survival rate is 94%.
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