Dr. M. R. Savita, G.M.C., Mysore
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Introduction: |
Acute diarrheal disorder is the leading cause of mortality and morbidity in children under 5 years of age in developing countries. Racecadotril is being proposed as a new “WONDER” drug in management of acute watery diarrhea in children.
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Objective: |
To assess the efficacy and adverse effects profile of Racecadotril in Indian children with acute watery diarrhea.
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Design: |
Double blind, randomized placebo controlled clinical trial.
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Setting: |
Urban teaching hospital and a referral center.
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Subjects: |
Children aged less than or equal to 5 years with acute diarrheal disorder.
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| Methods: |
60 Children aged less than or equal to 5 years with acute diarrheal disorder of 5 days duration or less, were randomized into Racecadotril group (n = 30) or placebo group (n = 30) in addition to oral rehydration therapy. The mean duration of diarrhea and vomiting after randomization, total ORS intake and time taken for correction of dehydration were assessed.
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Results: |
The baseline characteristics before randomization were comparable between Racecadotril and placebo group. Racecadotril group had a significant reduction in duration of diarrhea [40 hrs Vs 61.6 hrs in placebo group, p<0.01] and total ORS intake [841.67 ml Vs 1385 ml in placebo group, ‘P' < 0.001] No adverse effects were documented in the Racecadotril group.
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Conclusion: |
This study demonstrated that Racecadotril therapy is effective and safe in the management of acute watery diarrhea in children.
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Last Updated on 01-1-2006
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| How to cite this url |
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Karnataka Pedicon 2005 - Conference Abstracts.Pediatric Oncall [serial online] 2006 [cited 01 January 2006];3. Available from:
http://www.pediatriconcall.com/fordoctor/Conference_abstracts/
racecadotrial.asp
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