RACECADOTRIL - A NOVEL DRUG FOR TREATMENT OF ACUTE WATERY DIARRHEA IN INDIAN CHILDREN
Dr. M. R. Savita*
G.M.C., Mysore *
Introduction
Acute diarrheal disorder is the leading cause of mortality and morbidity in children under 5 years of age in developing countries. Racecadotril is being proposed as a new "WONDER" drug in management of acute watery diarrhea in children.
Objective
To assess the efficacy and adverse effects profile of Racecadotril in Indian children with acute watery diarrhea.
Design
Double blind, randomized placebo controlled clinical trial.
Setting
Urban teaching hospital and a referral center.
Subjects
Children aged less than or equal to 5 years with acute diarrheal disorder.
Methods
60 Children aged less than or equal to 5 years with acute diarrheal disorder of 5 days duration or less, were randomized into Racecadotril group (n = 30) or placebo group (n = 30) in addition to oral rehydration therapy. The mean duration of diarrhea and vomiting after randomization, total ORS intake and time taken for correction of dehydration were assessed.
Results
The baseline characteristics before randomization were comparable between Racecadotril and placebo group. Racecadotril group had a significant reduction in duration of diarrhea [40 hrs Vs 61.6 hrs in placebo group, p<0.01] and total ORS intake [841.67 ml Vs 1385 ml in placebo group, 'P' < 0.001] No adverse effects were documented in the Racecadotril group.
Conclusion
This study demonstrated that Racecadotril therapy is effective and safe in the management of acute watery diarrhea in children.
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Savita R M D.. Available From : http://www.pediatriconcall.com/fordoctor/ Conference_abstracts/report.aspx?reportid=174
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