A PROSPECTIVE STUDY OF CHILDREN WITH AUTOIMMUNE HEMOLYTIC ANEMIA IN A TRERTIARY CARE HOSPITAL
NATWAR SHARMA*, EZHILARASI. S**, SARALA RAJAJEE***
Kanchi Kamakoti Childs Trust Hospital. *, Kanchi Kamakoti Childs Trust Hospital. **, Kanchi Kamakoti Childs Trust Hospital. ***
Autoimmune Hemolytic Anemia is an entity resulting due to autoantibodies directed against red blood cells.
Objectives
To study the children with autoimmune hemolytic anemia, with respect to etiology, triggering factors and complications.
Design
Prospective descriptive study. Setting: Department of Hematology, from 1996-2005. Kanchi Kamakoti CHILDS Trust Hospital. Subjects and methods: 10 children with autoimmune hemolytic anemia in the age group 7 months to 15 years with equal male: female ratio and followed up over a period between 8 months to 10 years to assess the etiology, triggering factors for relapse, longterm outcome and complications.
Results
We had 10 children with Autoimmune Hemolytic Anemia in the age group of 7 month to 15 years. There were equal number of male and female children. Pallor (100%), fever (90%), Hepatosplenomegaly (70%), jaundice (50%) were the most common presenting features. 8 (80%) were idiopathic. Among them 6 (60%) were positive for warm antibodies and 2 (20%) were positive for cold antibodies, 2 (20%) were Anti Nuclear Antibody positive Systemic Lupus Erythematosus. All children received methylprednisolone followed by oral steroids. On follow-up 3 (30%) were well, 7 (70%) children relapsed all of which were precipitated by minor infections, 4 (40%) had only one relapse. One child was lost for follow-up. There was no mortality.
Conclusion
Autoimmune Hemolytic Anemia is a potentially fatal disease, which requires rapid recognition and continuing therapy. Relapse occurred in 7 (70%) of children associated with minor infections. 2 (20%) were part of Systemic Lupus Erythematosus. Mortality was nil.
Keywords
Autoimmune Hemolytic Anemia, Therapy, Outcome.
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