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LYMLPHOPENIA IN TB
Author : Pediatric Oncall

Question
A 7 years old boy had fever with limping 4 months back and left hip arthritis was detected for which arthrotomy was done and pus smear showed acid fast bacilli {AFB}. He was started on 4 drug antituberculous therapy {ATT}. His culture also grew mycobacterium tuberculosis {MTB} sensitive to all first line drugs. His hemogram 4 months ago showed lymphopenia {882 cells, cumm} which again after 4 months of therapy was 1364 cells, cumm. HIV ELISA was negative.

Answers of this discussion

Author :-

naresh tayade on 10 November 2011.

Answer :- if HIV is negative and lymphopenia persist most likely cause is like T- Cell defect and we required flow cytometry ,DTH test for diagnosis Dr. NARESH TAYADE

Author :-

sladjana bulatovic on 11 November 2011.

Answer :- antituberculotic drugs

Author :-

sladjana bulatovic on 11 November 2011.

Answer :- antituberculotic drugs

Author :-

manar on 12 November 2011.

Answer :- this is my be because of over whelming TB infection or due to drug reaction

Author :-

Mohsin Ali on 12 November 2011.

Answer :- Active TB suppress T cells

Author :-

adal arasan on 13 November 2011.

Answer :- increased phagocytosis

Author :-

safe ali on 14 November 2011.

Answer :- hypersensitivity mediated IFNandILs

Author :-

MUSTAFA SAAD on 17 November 2011.

Answer :- from tuberculous infection

Author :-

Abdul Rashid on 18 November 2011.

Answer :- Refractory lymphopenia due to severe infection

Author :-

Pediatric Oncall on 23 November 2011.

Answer :- Tuberculosis is one of the numerous conditions that may temporarily diminish lymphocyte subpopulations, producing the lymphocytopenia observed in some patients. Lymphopenia in patients with Tb is unrelated to the extent of lesions and prognosis. However it could be associated to a higher frequency of paradoxical reactions

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