Dr. M. R. Savita, G.M.C., Mysore
Acute diarrheal disorder is the leading cause of mortality and morbidity in children under 5 years of age in developing countries. Racecadotril is being proposed as a new WONDER drug in management of acute watery diarrhea in children.
To assess the efficacy and adverse effects profile of Racecadotrial in Indian children with acute watery diarrhea.
Double blind, randomized placebo controlled clinical trial.
Urban teaching hospital and a referral center.
Children aged less than or equal to 5 years with acute diarrheal disorder.
60 Children aged less than or equal to 5 years with acute diarrheal disorder of 5 days duration or less, were randomized into Racecadotril group (n = 30) or placebo group (n = 30) in addition to oral rehydration therapy. The mean duration of diarrhea and vomiting after randomization, total ORS intake and time taken for correction of dehydration were assessed.
The baseline characteristics before randomization were comparable between Racecadotril and placebo group. Racecadotril group had a significant reduction in duration of diarrhea [40 hrs Vs 61.6 hrs in placebo group, p<0.01] and total ORS intake [841.67 ml Vs 1385 ml in placebo group, P' < 0.001] No adverse effects were documented in the Racecadotril group.
This study demonstrated that Racecadotrial therapy is effective and safe in the management of acute watery diarrhea in children.
How to cite this url:
Karnataka Pedicon 2005 - Conference Abstracts.Pediatric Oncall [serial online] 2006 [cited 01 January 2006];3. Available from: