COMBINATION VACCINES
COMBINATION VACCINES
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Sayenna Uduman*, M I Sahadulla**, Raja Lakshmi***, Pretty G tharakan****
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Foreword
During the past two decades the number of injections that are required per clinic visit to fulfill the recommended childhood immunization schedule has been increasing dramatically. This has created problems for patients and practitioner, sometimes risking a missed opportunity for vaccination. Simplifying immunization schedules and to reduce the number of injections, combination vaccines have been developed by combining multiple vaccines into a single syringe. In this review, the combination vaccines (combos’) are defined as those containing various antigens to prevent different diseases or to protect against multiple strains of infectious agents causing the same disease.
Combos’ are available for many years include diphtheria and tetanus toxoids and pertussis vaccine (DTP); and measles-mumps-rubella (MMR). Also, the vaccines containing immunizing antigens against more than one serogroup or serotype of the same disease i.e. the pneumococcal, quadrivalent meningococcal and human papilloma virus (HPV) vaccines are symbolic. Improved vaccines are evolving continually & expected to be marketed for immunization purposes. The Health Ministry in each country has its own combos' preference and there has been no universally acceptable schedules in use.

Combos'
• A single injection that include immunizations against two or more diseases.
• Represent one solution to the issue of increased numbers of injections during single clinic visits and generally combo’s are preferred over separate injections of equivalent component vaccines.
• Can be used whenever any components of the combination are indicated and its other components are not contraindicated and got approved for use by the health and professional authorities (i.e. CDC , ACIP, COIDs, WHO, IAP etc) for that dose in the series.

References

Contributor Information and Disclosures

Sayenna Uduman*, M I Sahadulla**, Raja Lakshmi***, Pretty G tharakan****
*MD, FAAP
Visiting Professor, Infection Control Committee & ID Division of the KIMS
Thiruvananthapuram, Kerala, India

**CMD, ID Division, KIMS
***ID Consultant, KIMS
****Clinical Pharmacist, KIMS


First Created : 3/11/2016

References

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