Thrombocytopenia due to decreased platelet production is usually associated with other congenital abnormalities or evidence of systemic disease.

Genetic causes of thrombocytopenia in neonates (17) :-

• Thrombocytopenia with absent radii (TAR)
• Fanconi's anemia
• Congenital amegakaryocytic thrombocytopenic purpura
• Congenital hypoplastic thrombocytopenia with microcephaly.

• Bernard Soulier syndrome
• May-Hogglin anomaly
• Paris-Trousseau thrombocytopenia
• X-linked recessive thrombocytopenia

• Trisomy 13
• Trisomy 18
• Trisomy 21 (Mongol)
• Turner's syndrome

• Wiskott-Aldrich syndrome (WAS)
• Noonan syndrome
• Alpert's syndrome

• Methylmalonic acidemia
• Ketotic glycinemia
• Isovaleric acidemia
• Holocarboxylase synthetase deficiency