4th Pediatric Infectious Diseases Conference
 
 
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FIND DIAGNOSIS
FIND DIAGNOSIS
Find Diagnosis
Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)
ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)
Management and Prognosis
Management and Prognosis
Dr Vishal Dublish, Dr Ira Shah

Management:

Once ARDS sets in, it is a challenging task to manage. Still supportive therapy remains the first line of treatment.

General supportive management:
  1. Treatment of Sepsis: Sepsis should be aggressively treated with an adequate antibiotic regimen. Nosocomial infections should be prevented.

  2. Fluid management: It is suggested that reduced pulmonary artery pressure, weight loss and fluid restriction may improve outcome in ARDS including time on mechanical ventilation and days in intensive case unit. Increased intravascular hydrostatic pressure causes more alveolar fluid leakage and oxygenation worsens. Fluid restriction or diuretic may worsen shock by reducing cardiac output and organ perfusion. Optimal fluid management for patients with ARDS requires a balancing act between fluid restriction and fluid administration. Recent recommendations are in favor of small reduction in intravascular volume with diuretic use causing significant reduction in the extravascular lung water.

  3. Mechanical ventilation: is the mainstay of treatment. Goals of ventilatory support include:

    • Improving gas exchange

    • Reduce work of breathing

    • Avoiding oxygen toxicity

    • Minimizing high airway pressures

    • Promoting alveolar recruitment

    • Avoiding further lung damage and

    • Permitting lung tissue healing
This approach is called as "LUNG PROTECTIVE AND PRESSURE LIMITED STRATEGY"

Recent recommendations are:
  1. Using small tidal volumes (5-8 ml/kg).

  2. Longer inspiratory time via volume cycled ventilation or pressure targeted ventilation not to exceed transpulmonary pressure
    30-35 cm of water.

  3. Upward titration of PEEP (Peak end expiratory pressure).

  4. Allowing permissive hypercapnia, if necessary to reduce transpulmonary pressures.
Prone position ventilation: May improve oxygenation in more than 75% of ARDS patients. Proposed mechanisms are:
  • Redistribution of ventilation in the dependent lung zones with improved alveolar recruitment.

  • Increased drainage of airway and pharyngeal secretions

  • Redistribution of perfusion to less injured lung regions

  • Increased functional residual capacity (FRC)

  • Change in regional diaphragm motion
Limitations - Chances of extubation, central venous catheter removal, etc.





 
 
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