BONE MARROW INFILTRATION

The bone marrow may be infiltrated by nonneoplastic disease (storage disease) or neoplastic disease. In storage disease, a diagnosis is established on the basis of the clinical picture, enzyme assays of while cells or cultured fibroblasts and bone marrow aspiration revealing the characteristic cells of the disorder. Neoplastic disease may arise de novo in the marrow (leukemias) or invade the marrow as metastases from solid tumors (neuroblastoma or rhabdo-myosarcoma). Following table lists the diseases that may infiltrate the marrow.

Table : Spectrum of Systemic Lymphoproliferation in Children with AIDS