4th Pediatric Infectious Diseases Conference
 
 
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Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
DENGUE AND DENGUE HEMORRHAGIC FEVER DENGUE SHOCK SYNDROME
Dengue(Dengue Hemorrhagic) Fever and DSS
DHF/DSS and Lab Investigations
DHF/DSS and Lab Investigations
Dr Vishal Dublish, Dr Ira Shah

Dengue hemorrhagic fever / Dengue
shock syndrome (DHF / DSS):



  • Typically presents with high fever with hemorrhagic manifestations, liver enlargement with or without circulatory failure and thrombocytopenia.
  • Abnormal hemostasis with plasma leakage causes rise in hematocrit.
  • Sudden rise in temperature, pharyngeal congestion, abdominal pain, febrile convulsion are common.
  • Most common hemorrhagic phenomenon is positive tourniquet test, and early bruising with bleeding at venepuncture sites.
  • Rash is fine petechial or confluent on face, extremities, axilla, soft palate. Rash may be maculopapular also.
  • Epistaxis, gum bleeds, gastrointestinal hemorrhages occur occasionally. Rarely hematemesis may be seen.
  • Study from Chennai, India concluded that a combination of:

    • Biphasic pattern of fever
    • Hemoconcentration
    • Platelet count < 50,000/mm3
    • Raised aminotransferases.
    • Prolonged prothrombin time

      had a sensitivity of 79.2%, specificity of 64.7%, positive predictive value of 70% and negative predictive value of 75% in predicting spontaneous bleeding in Dengue infection.

  • Hepatomegaly can be tender in DSS. Jaundice is unusual and splenomegaly in rare in infants.
  • Chest X-Ray may show pleural effusion (more on right side).

Mild to moderate cases:
Fever subsides with profuse sweating. Mild changes in pulse rate and blood pressure may be noticed with cold extremities and skin congestion. Patient recovers spontaneously or after fluids and electrolyte therapy.

Severe cases:
Sudden deterioration may after few days. Fever subsides in 3-7 days and signs of circulatory collapse appear. Skin becomes cool, congested with circumoral cyanosis, weak and rapid pulse, acute abdominal pain and narrow pulse pressure (< 20 mm Hg). Consciousness is usually intact. Patient may die of profound shock if untreated or recovers after volume replacement. Complications include metabolic acidosis, severe gastrointestinal bleeds, intracranial hemorrhage, convulsions, encephalitis etc. Survivors recover within 2-3 days. Return of appetite is a good prognostic sign. During convalescent stage, bradycardia or arrhythmia may be noted.

Lab investigations:


  • CBC: Total leukocyte counts may be normal or leukopenia with relative lymphocytosis (> 15% atypical lymphocytes).
  • Platelet count is reduced
  • Hematocrit is Increased (> 20%) - suggesting increased vascular permeability and plasma leakage.
  • Urine - Transient and mild albuminuria.
  • Stool - Occult blood may be present
  • PT/PTTK - Prolonged, increased thrombin time.
  • Decreased fibrinogen, factor VIII, XII, antithrombin-III.
  • Decreased serum complement.
  • Severe liver dysfunction with reduced vitamin-K dependent factors and low serum proteins with raised aminotransferases.




 
 
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