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4th Pediatric Infectious Diseases Conference

ISSN 0973 - 0958

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Rakesh Kumar, Binay Ranjan, Manjul Vijay Department of Pediatrics, Katihar medical college, Katiha...

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Drug

Treatment Details

Ethylene glycol

It is a clear, colorless, odowebsiteess, non-volatile liquid with a bitter sweet taste mainly used as an anti-freeze agent.

Route : Not absorbed through skin

Fatal dose : 100 – 200ml

Fatal Period : 3days

Mechanism of action : It is metabolized to glycolaldehyde, glycolic acid and oxalic acid and inhibits oxidative phosphorylation

Clinical picture : • Initial symptoms : vomiting, lethargy, ataxia, convulsions and coma
• In 12 to 24 hours: tachycardia, tachypnoea, circulatory collapse aand acidosis
• In 1 to 3 days: hypocalcemia, oliguria, tubular necrosis an d renal failure

Treatment : • Gastric lavage
• Activated charcoal
• Antidote- Ethyl alcohol-1ml, kg, day as 111o percent solution I.V. for 5 days. Even 4-methyl pyrazole is considered to be a better antidote.
• I.V. sodium bicarbonate
• 10 percent calcium gluconate
• In severe cases – haemodialysis`

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Today’s Poll

Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?

No, it should be used only after drug sensitivity report

Yes, under guidance of an infectious disease expert

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