Poisning Center - Pediatric On Call

4th Pediatric Infectious Diseases Conference

ISSN 0973 - 0958

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Rakesh Kumar, Binay Ranjan, Manjul Vijay Department of Pediatrics, Katihar medical college, Katiha...

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Drug

Treatment Details

Digitalis purpurea (fox glove)

Route : Roots, leaves and seeds have the active principle- glycosides They are cumulative poisons

Fatal Period : 1- 24 hours

Mechanism of action : Act directly on the heart and improve the functioning of a failing heart, when taken in therapeutic doses. Death occurs due to cardiovascular collapse

Clinical picture : •Anorexia, nausea, vomiting and diarrhea
•Decreased heart rate, may be heart blocks, extra systoles and ventricular fibrillations
•ECG- flat or inverted T wave, depression of ST segment, prolonged PR interval and shortened QT interval
•Slow and sighing respiration
•Pupils dilated
•Visual disturbances
•Itching on skin
•May be delirium, hallucinations, convulsions and cardiac standstill

Treatment : •Stomach wash with tannic acid solution
•Bowels should be evacuated
•Activated charcoal in repeated doses
•Atropine 0.6mg i.v. for bradycardia
•Procainamide, quinidine or lignocaine for fibrillation
•Trisodium EDTA to lower serum calcium
•Potassium chloride
•i.v. glucose

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Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?

No, it should be used only after drug sensitivity report

Yes, under guidance of an infectious disease expert

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