Pompholyx is a non-inflammatory vesicular eruption in the palms & soles. It is a recurrent disorder with relapses frequently in patients with atopy, hyperhidrosis or neurovegetative states. It presents as severe itching over the hands & feet with appearance of vesicles over the lateral & volar aspect of fingers and toes. These vesicles arise from beneath the stratum corneum in the epidermis and are filled with clear fluid. They become painful as they grow in size.⁽⁴⁾ Secondary infection is frequent due to scratching.⁽¹⁾ The vesicles dry up and disappear within 2-3 weeks.⁽⁴⁾ With frequent relapses, the skin may become thickened, with uncomfortable fissured plaques. The diagnosis is clinical and may be mistaken for allergic contact dermatitis that usually affects the dorsal surfaces. Treatment consists of wet dressings and topical antibiotics for superadded infection during the acute phase.⁽¹⁾ Topical corticosteroids are the mainstay of treatment in the chronic phase.⁽⁵⁾ Other therapies in recalcitrant lesions tried are topical tacrolimus,⁽⁵⁾ low dose radiation therapy,⁽⁶⁾ Azathioprine,⁽⁷⁾ low dose oral methotrexate⁽⁸⁾ and tap water iontophoresis.⁽⁹⁾ Patient education about stress management and use of emollients is vital in preventing recurrence. Patients are also advised to avoid irritant, protect hands and avoid unnecessary exposure.⁽²⁾