DHA and Chronic Diseases - DHA in Pediatric Disorders,Other Effects

4th Pediatric Infectious Diseases Conference

ISSN 0973 - 0958

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DHA and Chronic Diseases

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DHA in Chronic Pediatric Disorders and other effects of DHA

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Essential fats: how do they affect growth and development of infants and young children in developing countries? A literature review

DOCOSAHEXAENOIC ACID (DHA) AND CHRONIC DISEASES

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Action of
DHA

DHA and Cardio vascular Effects

DHA and Mental Health

DHA Other Effects

DHA in Chronic Pediatric Disorders:

Low plasma and/or red blood cell DHA content has been documented in infants and children with fetal alcohol syndrome, attention deficit hyperactivity disorder, cystic fibrosis, phenylketonuria, unipolar depression, aggressive hostility, and congenital metabolic disorders, particularly adrenoleukodystrophy. (10)

Other effects of DHA:

Usefulness of DHA has already been established for visual performance. However it has been found that dietary DHA Omega-3 may protect against gum disease, act as anti-inflammatory agent for discogenic pain. Risk for colorectal cancer was 12% lower in those with adequate fish intake (fish being a good source of essential fatty acids). (4)

Conclusion:

Protective effect of DHA is most likely to be due to the fundamental properties of docosahexaenoic acid in cell function. Evidence shows that omega-3 PUFA play important roles in heart health, brain health, child and infant development, inflammation and other functions. Unfortunately the typical westernization of diet and Indian vegetarian diet does not supply enough EPA and DHA, which may contribute to increased risk of chronic diseases. (11)

References:

1.	Simopoulos AP. Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk. Exp Biol Med (Maywood). 2010; 235: 785-795
2.	BurdgeG. Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. Current Opin Clin Nutri Metab Care 2004;7:137–144
3.	SimopoulosAP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 2008; 233: 674–688
4.	DHA + EPA for Other Health Benefits and Chronic Disorders. Available at url: http://www.dhaomega3.org/Overview/DHA-%2B-EPA-for-Other-Health-Benefits-and-Chronic-Disorders. Accessed on 30th August 2010
5.	LewisRA, LeeTH, AustenKF. Effects of omega-3 fatty acids on the generation of products of the 5-lipoxygenase pathway. In: SimopoulosAP, KiferRR, MartinRE, eds. Health Effects of Polyunsaturated Fatty Acids in Seafoods. Orlando: Academic Press, 1986:227–238
6.	Lee JH, O'Keefe JH, Lavie CJ, Marchioli R, Harris WS. Omega-3 fatty acids for cardioprotection. Mayo Clin Proc. 2008 Mar;83(3):324-32
7.	Kris-Etherton PM, Harris WS, Appel LJ, American Heart Association Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease [published correction appears in Circulation. 2003; 107: 512.
8.	Ramakrishnan U, Imhoff-Kunsch B, DiGirolamo AM. Role of docosahexaenoic acid in maternal and child mental health. Am J Clin Nutr. 2009; 89: 958S-962S
9.	Dangour AD, Uauy R. N-3 long-chain polyunsaturated fatty acids for optimal function during brain development and ageing. Asia Pac J Clin Nutr. 2008; 17 Suppl 1:185-188
10.	Long-chain Polyunsaturated Fatty Acids in Chronic Childhood Disorders: Possible Additions to Special Products. Available at url: http://www.ifm.net/industry/lpufa.htm. Accessed on 30th August 2010
11.	Available at URL: http://www.goedomega3.com/ . Accessed on 30th August 2010

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