MALARIA

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Last Updated : 5/9/2005
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M.R.Lokeshwar
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Chronic complications
Tropical splenomegaly - This syndrome occurs in malaria endemic regions. WHO criteria for the diagnosis are :-
Major criteria : (a) Gross splenomegaly, (b) Immunity to malaria, (c) Serum IgM elevation > 2 SD i.e.1000 IU/ml. (d) Clinical & immunological response to antimalarial drugs

Minor criteria : (a) Hepatic sinusoidal lymphocytosis & Kupffer cell hyperplasia. (b) Cellular and humoral immune response to antigenic challenge. (c) Normal phytohaemagglutination,
(d) Hypersplenism, (e) Lymphoid proliferation, (f) Occurrence in the family.

Quartan Malarial Nephropathy : This entity is seen with P.malariae infection following immune complex injury to glomeruli resulting in nephrotic syndrome. Prognosis is guarded.



Contributor Information and Disclosures M.R.Lokeshwar
Consultant Pediatrician, Hinduja Hospital, Mumbai, India.


First Created : 4/2/2001
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