Selective IGA Deficiency : Cause, Symptoms, Diagnosis, Treatment


Last Updated : 8/4/2008
Font-size :  
Dr. Ira Shah

What is selective IgA deficiency


Selective IgA deficiency is a primary immunodeficiency in which IgA immunoglobulin is deficient in the blood and in the respiratory and intestinal tracts. IgA antibodies predominantly protect us from respiratory infections and diarrhea.

What is the

cause of selective IgA deficiency


The cause of selective IgA deficiency is not known.

What are the

symptoms of selective IgA deficiency


Most patients with selective IgA deficiency have no symptoms. Some people have a similar course as those patients with common variable immunodeficiency (cvid). Some patients may have recurrent Ear Infections, sinusitis, bronchitis, pneumonia and recurrent diarrhea. About 25% - 33% of patients with selective IgA deficiency may develop autoimmune diseases such as Rheumatoid arthritis, systemic lupus erythematosis (SLE) and immune thrombocytopenic purpura (ITP). Thus, these patients may get arthritis or low blood counts. Allergies are also common in individuals with selective IgA deficiency and asthma, food allergy, anaphylaxis is commonly seen.

How common is selective IgA deficiency?
Selective IgA deficiency is the commonest primary immunodeficiency. It is estimated that 1 in 500 people have selective IgA deficiency.

How is the
diagnosis of selective IgA deficiency

Absence of IgA immunoglobulin with normal levels of other immunoglobulins establishes the diagnosis of selective IgA deficiency.

What is the
treatment of selective IgA deficiency

There is no IgA replacement therapy currently. Treatment is directed towards management of the specific problem that the patient is suffering from.

Contributor Information and Disclosures Dr. Ira Shah
Consultant Pediatrician, Nanavati Hospital and B.J.Wadia Hospital for Children, Mumbai India

First Created : 1/8/2002
Last Updated : 8/4/2008
Contributor Information and Disclosures

Last Updated : 8/4/2008
Previous Authors :
Advertisements by :    Mega-CV by Aristo IndoIV by Sun Pharma
Disclaimer: The information given by is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.