Clinical clues from history and physical examination
Dysuria, loin pain, colic
joint pain, skin rash
Coagulation disorders, platelet deficiency
Family history of hematuria
Benign familial, Alport's syndrome, stones
|Sickle cell disease|
Renal angle tenderness
|Urinary tract infection|
Wilm's tumor, Polycystic kidney disease, hydronephrosis
Stones, UTI, hypercalciuria
Salient Features of selected diseases with hematuriaAlport's Syndrome
It is a triad of persistent hematuria, deafness, familial disease along with eye anomalies which progresses to chronic renal failure especially in males. It is inherited as sex linked recessive / autosomal recessive / autosomal dominant condition. No treatment is available except renal transplant when the child to progresses to ESRD.
It is a non-familial disease of unknown etiology. It presents with persistent microscopic and rarely macro hematuria. In majority of cases, it does not progress to ESRD in pediatric age. But 15% cases of IgA nephropathy in adults end in ESRD. Rarely nephrotic syndrome and hypertension is encountered after many years of onset.
Familial benign hematuria
It also presents with persistent microscopic hematuria and needs to be differentiated from Alport's syndrome since the prognosis is good in Familial benign hematuria whilst chronic renal failure occurs in Alport's syndrome. Final diagnosis is based on audiometry and kidney biopsy on EM.