HODGKIN'S LYMPHOMA

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Last Updated : 1/4/2011
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Bharat R Agarwal
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Hodgkin's disease has a bimodal peak with an early peak in late 20s and a second peak in late adulthood. In developing countries, the early peak occurs before adolescence. Hodgkin's disease is rare before 5 years of age. In children < 10 years, the incidence is more in boys. In developing countries, it has been associated with the presence of Ebstein Barr virus in the Reed-Sternberg.

Clinically, the patients present with painless enlargement of the lymphnodes, commonly in the supraclavicular and cervical region. The enlarged nodes are firm and rubbery. Sometimes the nodes may fluctuate in size. Almost 60% of the patients may have mediastinal disease at diagnosis. Patients may also have systemic symptoms such as fever, night sweats and weight loss most probably due to release of lymphokines by the Hodgkin's cells. The disease spreads contiguously via the lymphatics from one node to another; in later stages it may disseminate to organs.



Contributor Information and Disclosures Bharat R Agarwal
Pediatric Hematologist- Oncologist, Division of Pediatric Hem-Onco, B.J. Wadia Hospital for Children, Mumbai, India


First Created : 1/4/2001
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