A: In first 2 years of life, incidence of Rickets is 5 to 20%. Neonatal rickets is believed to be of multifactorial origin. Major contributing factors are related to nutrition, immaturity of enzyme systems & iatrogenic / metabolic factors. Premature infants of low birth weight are primarily affected. Bony changes appear around 2 months of age. The most frequent causes of Rickets in patients under 6 months of age also include conditions like Biliary Atresia.

A: Complete healing & restoration of normal structure are rule in rickets, however distortion/ sclerosis of spongiosa in affected segment may occur after healing & may remain visible for several years. Cortical thickening of segments of bone involved during active stage also may persist. Angulation deformities secondary to pathological fractures result in deformities like knock-knee, bow leg and sabershin.

Also See "Biochemical profile in Pattern of active rickets"

Last updated on 13-01-2001