4th Pediatric Infectious Diseases Conference
 
 
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Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
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JUVENILE RHEUMATOID ARTHRITIS
JUVENILE RHEUMATOID ARTHRITIS
Dr Gurmeet Mangat,
Consultant Rheumatologists, P.D.Hinduja Hospital.

Clinically, a diagnosis of juvenile arthritis is made if there is pain, swelling and stiffness in one or more joints in patients up to the age of 16 years.

It is found that JRA occurs to the extent of 30% in some population studies. It reportedly occurs in 1 in every 10,000 children every year. Although there are good descriptive series from different part of the country, there is a lack of accurate epidemiological data. The age of onset is often below 5 years and girls tend to be affected twice as frequently as boys.

Types

It should be emphasized that although these disorders come under the broad heading of arthritis depending on the disease, the predominant affliction may be related to other organ systems rather than the joints. Table I describes the common forms of arthritis encountered and their main modes of presentation.

TABLE I: Important Types of Juvenile Auto-immune Arthritis

Type of Arthritis Modes of joint involvement Extra-articular features (% : occurs only in a proportion of patients)
Juvenile idiopathic arthritis Persistent arthritis of more than 6 weeks of one or more joints Fever, intermittent rash, subcutaneous nodules, other organ system involvement ;
Juvenile systemic lupus erythematosus Arthralgias and arthritis Malar rash, oral ulcers, hair loss, fever, loss of appetite & weight. Other organ system involvement importantly hematological, neurological and the renal may be involved.
Juvenile myositis Joint pains more than arthritis.Patient complains more of muscle pain with weakness Diffuse rash, rash around the eyes, involvement of other organ systems importantly lung and neurological
Juvenile scleroderma Arthralgia or Arthritis Raynaud's phenomenon, sclerodactyly, pitted scars, finger tip ulcers, interstitial lung disease
Juvenile vasculitis    
Henoch Schonlein Purpura Arthralgia / arthritis Red palpable rashes especially in the lower limbs. Haematuria and bleeding per rectum
Kawasaki's disease Arthritis / arthralgia Mucocutaneous lesions & lymphadenopathy. Coronary vascular involvement.
Other vasculitis Arthritis / arthralgia Lung/kidney/sinus involvement in Wegener's granulomatosis. Eosinophilia with lung involvement in Churg Strauss disease. GI/Kidney/nerve involvement in polyarteritis nodosa. Kidney / nerve involvement in microscopic polyangiitis.


Although there are many different types of juvenile arthritis, a logical process of assessment can often lead to proper diagnosis and management. The mode of onset, type of joint involvement, the other associated organ system involvement and the attendant systemic features like fever, rash, weight loss etc. can all help in ascertaining the diagnosis.

Juvenile idiopathic arthritis: Here, the dominating clinical feature is painful swelling and stiffness in the joints. Depending on the number of joints involved this disease is further divide into 3 main categories. Pauci-articular (if < 4 joints are involved), polyarticular (> 4 joints are involved) and systemic onset disease (high-grade fever, rash and often other organ system involvement).

Juvenile systemic lupus erythematosus: The disease is characterised by fever, rash on the face, hair loss, oral ulcers and arthritis. Kidney disease is an important complication, occurring in a proportion of patients.

Juvenile myositis: Here, the child presents with muscle pains, weakness and diffuse rash. The rash can also be characteristically localized to the eye lids and knuckles.

 
 
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