ANAPHYLAXIS

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Last Updated : 4/19/2016
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Mitchell Lester
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INTRODUCTION
Abbreviations used:
FceR1: High affinity IgE receptor
IgE: Immunoglobulin E
IgG: Immunoglobulin G
NSAID: Non-steroidal anti-inflammatory drug
NPV: Negative predictive value
PPV: Positive predictive value
RAST: Radioallergosorbent test


Anaphylaxis is a relatively common and potentially life-threatening occurrence in the pediatric population. Fortunately, anaphylactic deaths are rare with potentially life-saving early intervention.

Anaphylaxis was described in 1902 by Frenchmen Richet and Portier. In their efforts to immunize dogs to sea anemone toxin, some dogs who previously tolerated sub-lethal doses died after receiving even smaller doses. They coined the term “anaphylaxis” (“without protection”), literally the opposite of prophylaxis. Richet received the 1913 Nobel Prize in Medicine for their work.

The incidence of anaphylaxis increased in the late 20th century with rates as high as 50/100,000 person-years. The prevalence of anaphylaxis in North America is about 1%. Every year in the United States an estimated 150 anaphylactic deaths are attributable to food, 50 to venom, and up to 600 from medications. The incidence and prevalence appear to be highest in children and decrease with age.

This review will stress the importance of early recognition and treatment of anaphylaxis and identify its most common causes.

References

Contributor Information and Disclosures Mitchell Lester
FABAI
Fairfield County Allergy, Asthma, and Immunology Associates Norwalk,
Connecticut, USA


First Created : 2/23/2001
Last Updated : 4/19/2016
References
Contributor Information and Disclosures

Last Updated : 4/19/2016
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