4th Pediatric Infectious Diseases Conference
 
 
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Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
PNEUMONIAS IN CHILDREN
Pneumonias in Children
Cephalosporins
Cephalosporins
Dr Ira Shah
M.D, DCH (Gold Medalist), FCPS, DNB

First generation cephalosporins:
They are useful against gram positive organisms and Proteus mirabilis, H influenzae, Escherichia coli, Klebsiella pneumoniae, and Moraxella catarrhalis.

  • Cephalexin: 50 mg/kg/day PO bid
  • Cefadur : 30-50 mg/kg/day PO bid.
  • Cefuroxime: 30 mg/kg/d PO bid, IV: 150-200 mg/kg/d IV divided q8h.
  • Cefalothin: 50 mg/kg/day PO qds / 100 mg/kg/day IV qds.

Second generation cephalosporin:
They are useful against gram positive organisms and have limited activity against gram negative organisms.

  • Cefaclor: 20-40 mg/kg/day PO tds.

Third generation cephalosporins:
They are broad-spectrum antibiotics having good gram-negative activity.

  • Cefixime: 8 mg/kg/day PO bid.
  • Ceftriaxone: 50-100 mg/kg/d IV/IM bd not to exceed 1 g.
  • Cefotaxime: 100-200 mg/kg/d IV/IM divided q6-8h.
  • Cefpodoxime: 10 mg/kg/d PO divided bid
  • Cefprozil: 30 mg/kg/d PO divided bid

Chloramphenicol: It is a bacteriostatic drug having good gram positive and gram negative coverage. It is given along with penicillin and is especially useful in patients with H. influenza infections. Dose: 100mg/kg/day IV/IM.

Septran : 21 mg/kg/day PO/IV for 21 days. Useful for PCP pneumonia.

Macrolides: They are used for treatment of staphylococcal and streptococcal infections. Also used in the treatment of atypical pneumonias due to mycoplasma, chlamydias.

Vancomycin is used in children with penicillin resistant streptococci and methicillin resistant staphylococci. Dose: 45-50 mg/kg/day IV qds

viral pneumonia:

  • RSV: Serious infections with this organism usually occur in infants with underlying lung disease. Aerosolized ribavirin can be given to severely affected infants.
  • Herpes virus: Acyclovir is available for treatment of these pneumonias. Dose: 10 mg/kg/dose IV q8h; infuse over 1 h
  • Influenza A pneumonia, which is particularly severe or when it occurs in a high-risk patient, may be treated with amantadine.
  • Children who are toxic: Antibiotic therapy should include vancomycin (particularly in areas where penicillin resistant streptococci have been identified) and a cephalosporin.



 
 
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