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Question

Female child years old with chronic pallor for 2 years and needed blood transfusion 4 times previously. there is no fever , hepatosplenomegaly or lymphadenopathy Investigations: HB : 5.5 gm/dl RBCs : 2500000 platelets : 120000/cc wbcs : 11000 hb electrophoresis : Hb A1

Answer

Since there is no hepatosplenomegaly and the child requires repeated transfusions, one shoudl rule out nutritional anemia, chronic blood loss as in worm infestation and also maybe a bone marrow examination since 2 cell lines (HB and platelets) are low. On needs a very good CBC with all indices and reticulocyte count with peripheral smear examination to decided on further line of investigation. Other chronic infections such as HIV, Hepatitis B should also be ruled out.
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