4th Pediatric Infectious Diseases Conference
 
 
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Specialist Answers
Question
What is the clinical significance of primitive reflex? Why does cataract occur in congenital rubella syndrome? where is the site of lesion in atonic cerebral palsy? Why do seizures occur in hypoglycemia, hypocalcemia and hypoxic ischemic encephalopathy?
Answer
A primitive reflex is one which gives for a more mature movement of the body to occur as the CNS matures. Primitive reflexes in a newborn allow for movement, feeding. Once more development occurs, primitive reflex gives way for a refined movement to take place.


Site of lesion in atonic CP would be in the cortex, cerebellum or basal ganglia. If it remains atonic, it is cerebellum. If it evolves into dystonia or choreoathetosis, it is basal ganglia and if it becomes spastic it is cortex and pyramidal tracts.

Seizures occurs in hypoglycemia, hypocalcemia and hypoxic ischemic encephalopathy due to ischemia and hypoxia leading to decreased substrate to the brain leading to lower threshold of electrical activity and seizure.
 
 
 
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Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
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