HIV In Children
 
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Specialist Answers
Question
What is pathogenesis for polycythemia in infants of diabetic mothers?
Answer
In infants of diabetes mothers the fetus is subjected to high levels of glucose during times of maternal hyperglycemia. After 20 weeks' gestation, the fetus responds to hyperglycemia with pancreatic beta-cell hyperplasia and increased insulin levels. Chronic fetal hyperglycemia and hyperinsulinemia increase the fetal basal metabolic rate and oxygen consumption, leading to a relative hypoxic state. The fetus responds by increasing oxygen-carrying capacity through increased erythropoieten production, possibly leading to polycythemia.
 
 
 
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Today's Poll
For treatment of tuberculosis, should anti TB drugs be given as fixed drug combination {FDC} or singly_?
FDC can be given as it is easy to give just one tablet
Drugs should be used singly to achieve optimum blood levels
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