4th Pediatric Infectious Diseases Conference
 
 
Home  Back   ISSN 0973 - 0958
 
User name :
Password :
Follow Us : Follow On Facebook Follow On Twitter Follow On Youtube
Specialist Answers
Question
3.5 yrs girl, II degree consanguinity product,2 normal older siblings, mother had jaundice in 1st TM of pregnancy ,mild dev .delay. She had grade I hepatic encephalopathy with HAV 6months back. 3 episodes of para/quadriparesis of mod-severe degree & loss/grossly altered speech lasting for 5-10days over last 15 mths were present. Fever ppt. once, focal seizures occurred once. Workup(KEM-PUNE)-gen. Spikes & wave on EEG,CT(old)-WNL,MRI-enhancement-rt.temporal/parietal lobes & choroid plexus,normal myelination. blood & csf lactates were raised. LFT-WNL. ? MELAS/Leighs. suggest diagnosis & further workup...
Answer
Since CSF lactate is raised and there have been 3 episodes of encephalopahty, one must work up for inborn error. A urine organic acids and urine for dicarboxylic acid should be done. Do a serum ammonia. Also and EMG to look for myopathy. A muscle biopsy may be indicated if strongly suspecting MERRF or MELAS. Specific enzyme analysis will depend on the further workup.
 
 
 
Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
Educational Section
 
Disclaimer:
The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
 
copyright ©2011 website design & development by Levioza
Follow Us
Follow us on :
Folllow Us