K is a 2.5 yr male child presented with h/o multiple fractures of different bones at different times (within a span of 6 months).he was well apparently upto 2 yrs of age. At the age of 2 yrs (6 months back) had trivial trauma, followed by fracture (1st) of left humerus followed by sub acute osteomyelitis which was treated appropriatel.2ndfracture after 1 month gap, right arm bones with radiologically s/o periosteal reaction with F/O osteomyelitis, which needed fixation with screws.3rd was fracture seperation of right tibial epiphysis, which was treated with POP cast. At present (4th) he has swelling of left knee with radiological evidence of periosteal reaction. Otherwise apparently well child upto 2 yrs of age. (Birth and developmental history is normal Physical examination revealed swelling of left arm and right knee joint, left arm is covered with cast. No blue sclera, no hearing abnormality, otherwise well and active child. Investigations normal total count, platelet, differential count, LFT normal, calcium and alkaline phosphatase were also normal, blood culture sterile. X-rays of affected parts is showing perioteal reaction, with fracturesof bone. Bone biopsy showing evidence of new bone formation with marked osteoblastic activity with no significant inflamation. Bone culture sterile.MRI done at the time of 2nd fracture was reported as subacute osteomyelitis of left distal humerus and supracondylar fracture of right humerus. Bone scan is showing i9ncreased osteoblastic activity involving right humerus and right femur with no definite evidence of bony inflammation. Immunoglobin profile is norml, NBT reduction is also normal.