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Question

infant of 6 month old ,consangiunous marraige, history of birth asphyxia, developed intermittent fever since 5 months with hypotonia developmental delay, treated by antimalaria was quinin infusion and cefitriaxon for persumed sepsis but fever persist , hb electrophoresis AS , torch screen was normal urin showed Wbc > 20 treated for UTI according to cultur but no response.bone marow revealed eosinophilia. mantoux was 9 mm , trial by antiTB started 20 days but still febril, hypotonic more, pale, brain CT scann showed mild cortical atrophy.what you suggest to do with this child

Answer

Since she has eosinophilia, one should rule out malignancy, Hyper IgE syndrome and idiopathic hypereosinophilia syndrome.
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