Dose and Schedule Of Ibuprofen in Treatment of PDA

4th Pediatric Infectious Diseases Conference

ISSN 0973 - 0958

Neonatal Hyperbilirubinemia

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Rakesh Kumar, Binay Ranjan, Manjul Vijay Department of Pediatrics, Katihar medical college, Katihar...

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	Specialist Answers
Question
1.What is the dose and schedule of Ibuprofen in the treatment of PDA? Are there any trials of Inj. Voveran in the treatment of PDA as it the only injectable alternative to Indomethacin in India? 2. Is there any modification to the Immunization schedule in a neonate who has undergone exchange transfusion? 3.What is the dose and duration of treatment. With Agaragar in a case of unconjugated Neonatal hyperbilirubinemia?
Answer
The dose for treatment of Ibuprofen for treatment of PDA is 10mg/kg loading dose followed by 5mg/kg 12hourly for 2 doses. At present, we are not aware of any trials of Inj Diclofenac in treatment of PDA. A child who has had exchange transfusion should not be given any vaccine for 6-8 weeks as the immunoglobulins present in the donated blood may interfere with the vaccination and lead to suboptimal response. Though agar alone is not recommended for treatment of unconjugated hyperbilirubinemia, it has been used in combination with photo-therapy in the dose of 1g/kgd orally in 4 divided doses till the serum bilirubin falls to a level where it does not require photo-therapy. However, its usefulness is still undetermined. Back to All Questions

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