Is adrenline nebulizer safe and effective in cases of acute bronchiolitis? What is it's dose and dilution? How frequently it may be repeated? Is it preffered over solbutamol?

Adrenaline has many theoretical advantages over salbutamol. It can decongest mucosa with alpha adrenergic vasoconstrictor action and this may in addition lead to decreased systemic absorption resulting in less tachycardia than salbutamol. With beta 2 adrenergic effect smooth muscle relaxation occurs, and antihistamine effect results in decreased edema and reduced catarrahal secretions. Studies comparing the two drugs are almost unanimous in showing adrenaline better than salbutamol. Dose used is 0.1 ml/kg body weight of 1 in 10,000 solution of adrenaline

Ref:
Reijonen K, Korppi M, Pitkakangas S et al. The clinical efficacy of nebulized racemic epfinerine and albutermol in acute bronchiolitis. Arch Pediatr Adolsec Med 1995; 149: 686-692
Menon S, Sutcliffe T, Klassen TP. A randomized controlled trial comparing the efficacy of adrenaline with salbutamol in the treatment of acute bronchiolitis. J Pediatr 1993; 122: 145-151
Bertand P, Aranibar H, Castro E et al. Efficacy of nebuized adrenaline versus salbutamol in hospitalized infants with bronchiolitis. Pediatr Pulmonol 2001; 31: 284-288.
Ray MS, Singh V. Comparison of nebulised adrenaline versus salbutamol in wheeze associated infants. Indian Pediatr 2002;39: 12-22.