4th Pediatric Infectious Diseases Conference
 
 
Home  Back   ISSN 0973 - 0958
 
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Specialist Answers
Question
Can you please tell me the features of pseudolymhoma syndrome caused by prolonged use of phenytoin? Will it produce hepato- splenomegaly along with generalized lymphadenopathy? What will be the histo pathology of such a lymph node?
Answer
Patients receiving phenytoin may develop pseudolymphoma or, rarely, malignant lymphoma and mycosis-fungoides-like lesions. Lymphoid hyperplasia can be localized in the cervical area. Enlargement of inguinal lymph nodes during chronic phenytoin therapy has been reported.
Most patients present with a single, slowly enlarging, papular, nodular, or plaque like lesion several weeks following the initiation of anticonvulsant medications. However, several patients have demonstrated drug-induced pseudolymphoma after more than 5 years of therapy.
Immunophenotyping of the lymphoma is essential to make the diagnosis. Most drug-induced pseudolymphomas contain CD3+CD4+ T cells
Other physical findings may include splenomegaly, marked localized or diffuse lymphadenopathy, and high-grade fever.
 
 
 
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Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
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