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| SPECIALIST ANSWERS
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Question |
1) If mantoux test has been don in pt.Recently can p.C.R/elisa be done in this Patient? 2)what are indication of pam in o.P.Poisoning? Are there any theraputic guidelines in this regard?
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Answer |
There is no contraindication to PCR or ELISA test after mantoux test.
PAM is used as an antidote to reverse muscle paralysis as it reactivates the phosphorylated AChE by binding to the OPC. It is ineffective once the OPC has bound AChE irreversibly and hence needs to be administered within 48 hours of exposure. Dose recommended is 20-40 mg/kg IV in 100 ml NS/D5 over 15-30 min to be repeated in 1-2 hours if muscle weakness is not relieved. PAM can precipitate myasthenia gravis and muscle rigidity in healthy volunteers.
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