4th Pediatric Infectious Diseases Conference
 
 
Home  Back   ISSN 0973 - 0958
 
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Specialist Answers
Question
The half life of dexamethasone is 24 hours, then why we are giving it sixth hourly in treatment of bacterial meningitis?
Answer
Dexamethasone has been recommended as adjunctive therapy in children with bacterial meningitis, because the drug significantly reduces inflammation in the central nervous system (CNS). Clinical and laboratory abnormalities resolve more quickly and long-term neurologic sequelae are reduced in infants and children who receive dexamethasone, compared with children who receive placebo. Adverse effects of dexamethasone in children with bacterial meningitis have been limited mainly to gastrointestinal bleeding.
Injections of dexamethasone give maximum plasma concentrations of dexamethasone at 1 hour. The biological half-life of dexamethasone is about 190 minutes.
 
 
 
Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
Educational Section
 
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