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| SPECIALIST ANSWERS
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Question |
Respected madam cefoperazone+sulbactum by ipca (lactagard) has 2:1 proportion and old brands were with 1:1 ration(zostum). which is rationale combination ?
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Answer |
Sulbactam combines with some clinically relevant beta lactamases in an irreversible manner. If sufficient inhibitor is present at the site of infection, the beta-lactamase enzymes should be neutralized and thus the drug used in combination with the inhibitor should have an opportunity to inhibit bacterial growth. 2 parts cefoperazone combined with 1 part sulbactam ratio resembles the expected levels in blood shortly after administration. The half-life of cefoperazone is much longer than that of sulbactam and thus the ratios will change with time.
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