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Question

I have seen that pts are in habit of misusing nimesulide.And if the pt is seen after two to three days after receiving b d doses of nimesulide there is periorbital swelling.Can it be some water retention of some nephrotoxicity.I have even seen generalised edema in pts on receiving nimesulide,especially if coprescribed with cefadroxil.

Answer

Nimesulide is known to cause both hepatotoxicity and renal toxicity. Since you have seen these adverse effects why don't you report it in our ADRIS (ADVERSE DRUG REACTION INFORMATION SYSTEM) section so that more and more people become aware of this problem. You can access the link given below:

http://www.pediatriconcall.com/fordoctor/adris/adris_list.asp
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