Central Pontine Myelinosis - Pediatric Oncall

4th Pediatric Infectious Diseases Conference

ISSN 0973 - 0958

Electrolyte Imbalance

Clinical Tools

Clinical Vignettes

Diseases & Conditions

Drugs Interaction Calculator

Podcasts

Patient Management Online

Diagnostic Dilemma

Question of the Day

Medical Quiz

Interactives

Ask Queries

SPECIALIST ANSWERS

Rakesh Kumar, Binay Ranjan, Manjul Vijay Department of Pediatrics, Katihar medical college, Katihar...

Video Podcast

Videos in Medicines

Medical Training Videos

Clinical Video Resource

Videos on Asthma

Audio Cast

Lecture on Pediatrics

Medical Training Audios

Clinical Audio Resources

Audios on Asthma

Mobile (wap)

Staying connected to Pediatric Oncall is now easier with Pediatric Oncall Mobile . You can now download selected content from the latest issue of Pediatric Oncall.

Research Grant

FIND DIAGNOSIS

VACCINE REMINDER

Get the Vaccine Schedule for your child."

	Specialist Answers
Question
What is meant by central pontine myelinosis? Q.2 What happens to Na in DKA. Please give me some information regarding corrected sodium also.
Answer
Sodium is the most important cation contributing to extracellular osmolality. Except for transient changes, the extracellular fluid and intracellular fluid are in osmotic equilibrium. Hypernatremia leads to increase in the volume of extracellular water with cerebral dehydration. Over distension of cerebral vessels leads to distension of cerebral vessels leading to subdural, subarachnoid and intracerebral hemorrhage. As a protective mechanism, the brain appears to generate new intracellular solute called as idiogenic osmoles. Intracellular osmolality is thereby increased, minimizing the loss of intracellular brain water. Rapid correction of such a hyperosmolar state may lead to excess movement of water into the cerebral cells due to the idiogenic osmoles leading to cerebral edema. Occasionally, this cerebral edema may be irreversible and fatal. Thus, a rapid rise or rapid fall in the serum sodium levels induces osmotic stress against a background of metabolic imbalance with osmotic opening of the blood-brain barrier or osmotic vascular injury. This results in cerebral edema and/or release of myelinotoxic factors which in turn may lead to demyelination and cellular injury. In adults, the osmotic vascular injury and cytotoxic edema is principally derived from the highly vascular grey matter which affects the adjacent myelinated white matter leading to demyelination of all regions in the brain, the pons has the greatest degree of grey-white apposition. Areas such as the striatum, thalamus, geniculate bodies and cerebral cortex-white matter junctions also have apposition of grey and white matter thus leading to central pontine myelinolysis (CPM) Back to All Questions

Diseases & Conditions

Pediatric Oncall Journal

Pediatric Conferences

Ped Tools

Adverse Drug Reactions

Head circumference Calculator

Mid parental height Calculator

Body surface area Calculator

BMR Calculator

Temperature Calculator

Anion gap Calculator

Today's Poll

Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?

No, it should be used only after drug sensitivity report

Yes, under guidance of an infectious disease expert

Vote

Results

Pediatric oncall book store

Partner Sites

Infection in Children

Pedcall

Medical ADRIS

Vaccine Reminder

Pediatric Oncall Journal

Educational Section

Disclaimer:

The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.

Sitemap For Doctor

Sitemap For Parent

Sitemap For Kids