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| SPECIALIST ANSWERS
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Question |
Any effective therapy for leukodystrophy? except for Lorenzo's oil (in select cases). How to control seizures in them? Most importantly how to apprach to manage and prognosticate such kids? This site does not have single search result on it?
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Answer |
There are various types of leukodystrophies namely:
The Leukodystrophies (in alphabetical order) The known leukodystrophies are listed below.
18q Syndrome with deficiency of myelin basic protein
Acute disseminated encephalomyeolitis (ADEM)
Acute Disseminated Leukoencephalitis
Acute Hemorrhagic Leukoencephalopathy
Adrenoleukodystrophy (ALD)
Adrenomyeloneuropathy (AMN)
Aicardi-Goutieres Syndrome
Alexander Disease
Adult-onset Autosomal Dominant Leukodystrophy (ADLD)
Autosomal Dominant Diffure Leukoencephalopathy with neuroaxonal spheroids
Autosomal Dominant late-onset leukoencephalopathy
Childhood Ataxia with diffuse CNS Hypomyelination (CACH or Vanishing White Matter Disease)
Canavan Disease
Cerebral Autosomal Dominant Arteropathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)
Cerebrtendinous Xanthomatosis (CTX)
Craniometaphysical dysplasia with leukoencephalopathy
Extensive Cerebral White Matter abnormality without clinical symptoms
Familial adult-onset leukodystrophy manifesting as cerebellar ataxia and dementia
Familial leukodystrophy with adult onset dementia and abnormal glycolipid storage
Globoid Cell Leukodystrophy (Krabbe Disease)
Hereditary adult onset leukodystrophy simulating chronic progressive multiple sclerosis
Lipomembranous osteodysplasia with leukodystrophy (Nasu Disease)
Metachromatic Leukodystrophy (MLD)
Megalencephalic leukodystrophy with subcortical cysts (MLC)
Neuroaxonal leukoencephalopathy with axonal spheroids
Oculodetatoldigital Dysplasia with cerebral white matter abnormalities
Orthochormatic leukodystrophy with pigmented glia
Ovarioleukodystrophy Syndrome
Pelizaeus Merzbacher Disease (X-linked spastic paraplegia)
Refsum Disease
Sjogren-Larssen Syndrome
Sudanophilic Leukodystrophy
Van der Knaap Syndrome (Vacuolating Leukodystrophy with Subcortical Cysts or MLC)
Vanishing White Matter Disease (Childhood ataxia with diffuse central nervous system hypomyelination, or CACH)
X-linked Adrenoleukodystrophy (X-ALD)
Zellweger Spectrum: Zellweger Syndrome, Neonatal Adrenoleukodystrophy, and Infantile Refsum Disease Management is supportive. BMT may be useful in X-linked adrenoleukodystrophy, metachromatic leukodystrophy.
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