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Question

Hi Doctor, My son is 1.5 months old. He is 5 weeks pre-turm baby. He has conjugated jaundice. We are Indian and now in UK. Recently Liver & Kidney have been scaned and found normal and no obstraction of biliary tree. So what will be next. His mum was affectedwith TORCH infection in her pregnancy. Please help. N.b I am not in this profession but seeking help.

Answer

In the neonate, sepsis is the most frequent cause and later biliary atresia (BA) is seen in as many as 75% of cases with conjugated hyperbilirubinemia. The list of causes is given below:

Infective, Inherited disorders such as Niemann-Pick Type C, Galactosemia, Alpa-1 antitrypsin deficiency, Biliary Hypoplasia (Syndromic), Cholestasis with actin and microfilament accumulation, Progressive intrahepatic cholestasis, Trisomy 13, Trisomy 18, Trisomy 21 etc.

Since the mother had TORCH infection in pregnancy, one should rule out TORCH in the baby
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