Anti-Inflammatory Dose of Aspirin in Kawasaki Disease

4th Pediatric Infectious Diseases Conference

ISSN 0973 - 0958

Kawasaki's disease

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Rakesh Kumar, Binay Ranjan, Manjul Vijay Department of Pediatrics, Katihar medical college, Katihar...

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	Specialist Answers
Question
Sir, now it has been recommended that in Kawasaki disease the anti-inflammatory dose of aspirin been reduced to 50mg/kg/day in 4 divided doses; almost half of the dose that we have been using so far. Has anyone tried this and is the effect and outcome similar? Thank you.
Answer
Although aspirin is part of standard therapy in KD because of its anti-inflammatory, antipyretic, and anti platelet effects, no prospective study has shown that aspirin at any dose reduces the incidence of CAAs. A US clinical trial by Melish18 compared IVIG 2 g/kg plus high-dose (100 mg/kg per day) aspirin with IVIG plus low-dose (3?8 mg/kg per day) aspirin and found that there was no significant difference between the two groups in the incidence of CAAs. A meta-analysis by Durongpisitkul et al19 demonstrated that high-dose (2 g/kg) IVIG therapy plus high-dose (>80 mg/kg) or lower-dose (<80 mg/kg) aspirin regimen was associated with a similar incidence of CAAs after disease onset (4.8% vs 4.0%). Ref: PEDIATRICS Vol. 114 No. 6 December 2004 However, further studies are required to determine whether aspirin is required or not in treatment of Kawasaki's disease. Back to All Questions

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