Neurofibromatosis - Pediatric Oncall

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Rakesh Kumar, Binay Ranjan, Manjul Vijay Department of Pediatrics, Katihar medical college, Katihar...

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	Specialist Answers
Question
How can I diagnose neurofibromatosis ? (I mean number & size of lesion) ---------Thanks------------
Answer
Diagnostic criteria for NF-1 (The diagnostic criteria are met if 2 or more of the features listed are present.) Six or more cafe au lait macules larger than 5 mm in greatest diameter in prepubertal individuals and those larger than 15 mm in greatest diameter in postpubertal individuals Two or more neurofibromas of any type or 1 plexiform neurofibroma Freckling in the axillary or inguinal regions Optic glioma Two or more Lisch nodules (iris hamartomas) A distinctive osseous lesion, such as sphenoid dysplasia or thinning of the long bone cortex, with or without pseudoarthrosis. A first-degree relative with NF-1 according to the above criteria. Diagnosis criteria for NF-2 (The criteria are met if condition 1 or 2 is present.) Bilateral masses of the eighth cranial nerve seen with appropriate imaging techniques (e.g., CT, MRI) A first-degree relative with NF-2 and either (a) a unilateral mass of the eighth cranial nerve or (b) 2 of the following: neurofibroma, meningioma, glioma, schwannoma, or juvenile posterior subcapsular opacity. Back to All Questions

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