4th Pediatric Infectious Diseases Conference
 
 
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Specialist Answers
Question
One & half year old boy-first product of II-consanguineous marriage had isolated progressive motor regression. MRI showed white matter disease with prominent post. & deep white matter involvement without contrast enhancement. Three senior pediatric neurologists have labeled it as leukodystrophy. VLCFA-WNL. Last neurologist bluntly conveyed poor outcome & non availability of any solution in allopathy & advised for help of alternative medicine. With no definite metabolic diagnosis, mode of inheritance how can this pessimistic approach be justified? Please answer in this regards- 1)Availability & usefulness of further diagnostic workup. 2)therapeutic options(in all existing pathies with some predictable help).
Answer
Since there is presence of leukodystrophy, apart from adrenoleukodystrophy, one must also rule out Krabbe's disease and MLD. Also vanishing white matter disease and PML (in HIV patients) should be kept in mind. Enzyme analysis can be done at PRL, KEM Hospital, Mumbai. The diagnosis of the specific metabolic disorder is very important for prenatal diagnosis and screening in next pregnancy.
 
 
 
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Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
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