4th Pediatric Infectious Diseases Conference
 
 
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Neuromuscular Disorder
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Specialist Answers
Question
My biggest problem is that my institute receives meningoencephalitis cases from all over Delhi and adjoining areas in such bad shape that we hardly have time to send cultures and work out a strategy. Most already having received the common third gen cephalosporins at private places for few days. Resultant we loose them without even giving a fight. we really helpless when it comes to encephalitis ( mortality rate being 60-70% in my experience) 2) please can you give me an approach regarding investigating and reaching a diagnosis, which is both speedy and cost effective in helping save such kids? 3) On what grounds can acyclovir be started? 4) Please also share the most effective strategy treatment wise keeping in mind the short window period that most of the times we have? Please help me at the earliest. Thank you!
Answer
It is a problem in dealing with these children especially since cost is a major factor to consider. For meningoencephalitis, one needs to distinguish between viral, bacterial and tuberculous etiology.
CSF examination is the most useful test. If the CSF sugar is still low, one needs to rule out between TBM and bacterial infection. In this case, imaging to look for basal exudates, hydrocephalus would be a useful pointer to TBM. A high WBC count on CBC would be a pointer towards bacterial infection.
Regarding viral infections, look for RBCs in CSF, normal CSF sugars. Herpes encephalitis may also cause temporal lobe lesions on imaging and EEG will show pleds. If you have strong suspicion of herpes, acyclovir may be started but one may consider doing CSF herpes PCR in such a case. If negative, it rules out Herpes.
Do not forget the use of steroids for bacterial and TB meningitis.
If cost is not a factor, PCR for various viral infections in the CSF can be done. CSF TB PCR may not be that reliable.
 
 
 
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