Amniocentesis - Prenatal Screening

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ISSN 0973 - 0958

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Rakesh Kumar, Binay Ranjan, Manjul Vijay Department of Pediatrics, Katihar medical college, Katihar...

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Question
I have written to you before, about my problem, I want to know something more about it, I am a 30 years old, in 24th week gestation in my 5 month. My ultrasound was done which was alright, in my 6 month my Dr. told me that my baby has thick nuchal fold, after that I went through the level 2 ultrasound, they told me that all the anatomy was alright, and the thickness is 9 mm. But we will be sure after amniocentesis. All my previous tests blood and urine are normal, inc AFP. Now please tell me that is 9mm a reliable indication for down syndrome.? how many chances are to have a DS at this thickness, will it be reduced to normal by the time of birth, Does the nuchal fold thickness advances with time of gestation? what is the normal thickness in all trimesters and at birth? Is amniocentesis safe and what are the hazards to do that at this time?
Answer
24 weeks would be a little difficult to do an amniocentesis. Also 24 weeks of gestation is the period when a viable baby can be born. Thus, medical termination of pregnancy may not be possible as an option. As states earlier, chances of Down's syndrome is rare in mothers below 30 years of age. The antenatal screening tests consist of - Triple test - Ultrasound - Amniocentesis The triple test can detect 60 percent of trisomy 21 pregnancies; it has a false-positive rate of 5 percent. The likelihood of fetus having trisomy 21 in a patient with a positive test is about 2 percent. Second-trimester ultrasound assessment may be helpful for predicting the likelihood of trisomy 21 in pregnancies at increased risk. First-trimester screening by means of maternal age and measurement of nuchal translucency could provide a trisomy 21 detection rate of 63 percent, with a 5 percent false-positive rate. Back to All Questions

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