4th Pediatric Infectious Diseases Conference
 
 
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Specialist Answers
Question
I have come to know about the role of lignocaine in neonatal seizures. Can you please tell me any centers in India using lignocaine for neonatal seizures and its success rate and side effects? Plus whether the same can be used in case of older kids who have refractory seizures. What will be the side effect profile in them like?? Please reply with satisfactory details. thank you.
Answer
Lidocaine is an effective drug for the treatment of neonatal convulsions not responding to traditional anticonvulsant therapy. However, one of the side-effects is a risk of cardiac arrhythmias. Doses that have been used are loading dose of 2 mg/kg in 10 min, followed by the continuous infusion of 6 mg/kg per hour for 6 h, 4 mg/kg per hour for 12 h and finally 2 mg/kg per hour for 12 h. Lignocaine has been used in older children with status epilepticus and has found good response.

Ref:
Dev Med Child Neurol. 2006 Mar;48(3):220-2
Eur J Pediatr. 2006 Sep;165(9):598-604. Epub 2006 May 12.
 
 
 
Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
Educational Section
 
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