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	Specialist Answers
Question Category : Thalassemia
ANTENATAL DIAGNOSIS OF SICKLE DISEASE & B THALASSEMIA MAJOR. If parents are sickle trait or Thalassemia minor which material to send for antenatal check up, at what stage of gestation, at which place and what is the cost of the test? Check Out the Answer
Question Category : Thalassemia
A thalasemic girl(Beta Thalassemia minor-HBA2-5) is having high iron binding capacity. Does she require Iron therapy? Advice to her before marriage? Check Out the Answer
Question Category : Thalassemia
Can a 2yrs old child having Thalassemia minor also have concomitant Iron deficiency? Will giving Iron supplements in this situation lead to Iron overload? Inv done have revealed Hb A2 as 4.5% HbF 2.1% HbA 93.4%,S.Iron 39mg/dl TIBC 510 mcg/dl %sat 7.6%. Check Out the Answer
Question Category : Thalassemia
A 3.5 years male child received 3 blood transfusions between March and May 2002 because of development of severe anemia( Hemoglobin. Ranging 4-5 Gm%).His pre transfusion Hemoglobin electrophoresis showed HbA-76.1%, A2-5.3%, F-5.8%, S-12.8% (Reference lab. Ranbaxy). He does not have splenomegaly and retic is 2% prior to transfusion. Why should a thal. minor and sickle trait combined child should have severe anemia to need Blood Transfusion? Check Out the Answer
Question Category : Thalassemia
How can one confirm hemoglobin E asin HPLC HEMOGLOBIN E G O arab migrate at same site A2. Check Out the Answer
Question Category : Thalassemia
Should we give thalassemic patient Folic acid? (why)? why do you give vitamin C? Check Out the Answer
Question Category : Thalassemia
I have a patient who has persistent fetal hemoglobin. He is 20 years old. He is well, did not need blood transfusion ever. Now he has yellow sclera and mild increase in the serum indirect bilirubin. What could be the cause? and will his children be like him? thanks. Check Out the Answer
Question Category : Thalassemia
9 years old girl who is known to have e-beta thalassemia, was slenectomised and had recurrent soft tissue swelling and arthropathy. She also had a bout of desentert preceding the onset of current symptoms. What could be the cause of it? Check Out the Answer
Question Category : Thalassemia
What can be the cause of bilateral occipital protuberance in a five year old multi-transfused thalasaemic patient? Check Out the Answer
Question Category : Thalassemia
What is the mode of inheritance of sickle cell disease? Check Out the Answer
Question Category : Thalassemia
Is Vitamin C therapy contraindicated in Thalassemic patients on deferral with cardiomyopathy in failure? Check Out the Answer
Question Category : Thalassemia
Hi, I have a few patients with cardiomyopathy secondary to cardiac siderosis (B thal patients)I am planning to start them on continuous infusion of deferral since they are in heart failure. what would be the method to do that? Check Out the Answer
Question Category : Thalassemia
What will be the peripheral smear finding in splenectomised thalessemia patients? What is the youngest age at which we can safely give ceftriaxone? What is the pathology of subcutaneous nodules? Check Out the Answer
Question Category : Thalassemia
A 9 year old child , product of consangineous marriage is brought to us with history of pallor. On examination child was markedly pale with thalassemic facies (prominent cheeks).On systemic examination, he had jaundice, with liver of 3cm below the right coastal margin and spleen just palpable. Others system were normal. Height and weight was normal for his age. There is no history of blood transfusion in the past. His mother is thalassemic carrier and one on his younger sister is thalassemic major being transfused every month. Our admitting diagnosis was hemolytic anemia most likely thalasemia intermedia. But lab shows picture as thalassemia minor as his HB electrophoresis showed HbA as 83.1%, HbA2 as 10% and HBF as 6.9%. Retic counts were 4%, Hb on admission was 5g/dl. His LFT's showed liver enzymes normal, bilirubin was 2.6mg/dl. His RDW was 42. Peripheral film show anisocytosis, piokiolocytosis and fragmented RBC. Urine R/E showed no bilirubin in urine. His Ferritin is 111ng/ml(N) My question is this child is clinically behaving as thalessemia intermedia but Hb electrophoresis show thalessemia minor picture. It is mentioned in literature that con-comitent iron deficiency anemia can interfere with HB electrophoresis by interfering with HbA2 being high. But how to diagnose iron deficiency anemia in thalassemic child when serum ferritin is 111ng/ml. What should be done further in this child to arrive at a conclusion? Check Out the Answer
Question Category : Thalassemia
What is starvation diarrhea 2) why jaundice is more common in thalassemia intermedia than thalassemia major 3) as per investigation concerned how a thalassemia patient is followed Thanks! Please answer my questions. Your website is a tremendous boost for me. And I would always like to participate whenever I get can Thanks! Dr.Mangesh Khandave. Check Out the Answer

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