Research Forum Blogs
Under Category :  Medical Research
Posted By :  Ira Shah
Posted On : 08 Jul 2010
Total Replies :  0
Sample Size
Thank you Dr Athreya for your comments. Yes, we are looking to see incidence and type of paradoxical reactions in children who are being treated for TB. This includes both HIV and non HIV infected children. Paradoxical reaction means worsening clinical or radiological symptoms inspite of response to anti TB therapy. This is similar to a condition called as IRIS in HIV infected individuals. This is known as immune reconstitution. Paradoxical reactions are seen in form of increase in size of lymphnodes or appearance of tuberculomas on treatment inspite of patient having response to therapy.

So now that we have defined the study purpose, how should be calculate sample size.
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